March 7, 2000 incident where McCain snaps at Maria Shriver (NBC correspondent at the time). You can hear him say "You are a...What?" Maria first asks "How do you feel?" then she asks something inaudible (What do you hear? Please post in the comments).

McCain - clearly offended - stops, turns to her and says "Please get outta here".

Maria Shriver said that the incident "was really shocking to (her)" and is still unresolved during an April 24, 2008 interview on the Colbert Report. Colbert described the incident as "McCain famously bit your head off...like Ozzy Osbourne with a dove". Maria stated that she just asked McCain "What is your reaction to these results (of the 2000 primary)".